Fimale akt

AKT is implicated in neurological disorders. Because sex is a determinant of these disorders but poorly understood, sex was an experimental variable in our design. Our studies revealed AKT isoform- and sex-specific effects on anxiety, spatial and contextual memory, and fear extinction. In Akt1 mutant males, viral-mediated AKT1 restoration in the prefrontal cortex rescued extinction phenotypes.
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03.01.2020
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Akt like a woman: gender differences in susceptibility to cardiovascular disease

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Akt like a woman: gender differences in susceptibility to cardiovascular disease

Metrics details. Its negative prognostic value has been proven in many types of cancer. Immunohistochemistry IHC was used to evaluate marker expression in tumor cells. The site of Akt phosphorylation seems to have gender-dependent impact on survival in STS patients. Soft tissue sarcomas STS are malignant tumors arising from extraskeletal connective tissues.
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